P2PSigLip: Proteome-Scale Protein Interaction Prioritisation
P2PSigLip is designed as a proteome-scale candidate prioritisation resource. Its scores are primarily intended to rank interaction candidates within a query or candidate pool for downstream structural modelling and experimental validation, rather than serving as calibrated interaction probabilities.
P2PSigLip uses frozen ProtT5 embeddings and dual projection heads to turn pairwise PPI screening into reusable retrieval. Each protein is embedded once, and proteome-scale all-vs-all scoring becomes a matrix operation rather than a separate forward pass per pair.
Under strict homology-controlled evaluation, the method improves partner-ranking performance over strong sequence baselines and matches or exceeds structure-aware references on several external benchmark settings. The resource is designed for candidate prioritisation at proteome scale.
The web resource exposes precomputed multi-species prioritisation-score sets so users can search by gene or protein ID, retrieve ranked partners, inspect local neighbourhoods, and download results without rerunning the scoring pipeline locally.